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ASCO半途而废胰腺癌幻灯片教养学.pptx 26页

时间:2019-10-02 10:36  来源:原创  阅读次数: 复制分享 我要评论

����A Randomized Phase II trial of Adjuvant Chemotherapy with S-1 vs S-1 and Gemcitabine(GS) vs Gemcitabine alone(GEM) in Patients with resected Pancreatic Cancer (CAP-002 study)Abstract No: 4056 Presenter: Hideyuki Yoshitomi, MD���Է�Ӧ��ˮ����GEM��(N=30)S-1��(N=31)GS��(N=31)3������16(53.3%)4(12.9%)25(80.6%) ѪҺ��15(50.0%)3(9.7%)20(64.5%) ��ѪҺ��4(13.3%)3(9.7%)7(22.6%)4������5(16.7%)0(0.0%)3(9.7%) ѪҺ��4(13.3%)0(0.0%)3(9.7%) ��ѪҺ��1(3.3%)0(0.0%)0(0.0%)����(3,4��)21(70.0%)4(12.9%)28(90.3%)����ˮ����ɹʹ�ͻ����ʵ��2��DFS����Ϊ25.1% vs 28.1% vs 34.4%; p=0.47 OS(��) ����Ϊ46.9 vs 68.8 vs 53.1; p=0.48���ۣ�S-1��ҩ��S-1��Ϲؼ��ʾ���ؼ��ʵ�ҩ��Ч��ͳ��ѧ�����ִ�֤�ؼ��ʵ���Ч�޷�����Խ��Hideyuki Yoshitomi ,et al. 2013 ASCO abstract: 4056JASPAC 01: Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancreatic cancerAbstract No: 4008 Presenter: Akira Fukutomi, MD�д�������ٰ�����ˮ��������д��յ���Ҫ�յ㣺OS��Ҫ�յ㣺RFS��AEs(CTCv3.0)���ؼ������QOL(EQ-5D)˳������10�ֲܷ�Ҫի�� �д����� R0/R1 N0/N1���GEM��1000mg/m2, d1,8,15��ÿ4������ 6������S-1��80, 100, 120 mg/��*��d1-28��ÿ6������ 6������*��������������(m2)BSA ��1.25, 1.25 �QBSA ��1.5, BSA �R1.5Akira Fukutomi,et al. 2013 ASCO abstract: 4008�����ص�GEM(N=191)N (%)S-1(N=187)N (%)���*66��(39-84��)66��(34-86��)������104(54)106(57)Ů87(46)81(43)ECOG PS0128(67)131(70)163(33)56(30)CA 19-9**�Q37146(76)151(81)��3745(24)35(19)����˳����PD#136(71)121(65)Զ��50(26)66(35)һ��5(3)0(0)˳���������ʱ��*48��(20-69��)˳������ĩ��β������ˮ��ʱ��*56��(20-97��)*����λ�����룩**��S-1��1�����߲����#����ʲ��ָ��˳����Akira Fukutomi,et al. 2013 ASCO abstract: 4008�����ص�GEM(N=191)N (%)S-1(N=187)N (%)ԭ������T112(6)11(6)T214(7)11(6)T3165(86)163(87)T40(0)2(1)�ܰͽ�N073(38)67(36)N1118(62)120(64)����I18(9)15(8)II173(91)170(91)III0(0)2(1)�����������R0165(86)164(88)R126(14)23(12)Akira Fukutomi,et al. 2013 ASCO abstract: 4008OS�����ռ�����(219������)Akira Fukutomi,et al. 2013 ASCO abstract: 4008RFS�����ռ�����(273������)Akira Fukutomi,et al. 2013 ASCO abstract: 4008AEsCTCAE V3.0GEM(N=191), %��ӵ�м���3��4��S-1(N=187)��ӵ�м���3��4���R3��AEPֵ��ϸ��������94.231.96.855.13.74.8��0.001��ϸ��������95.845.526.774.911.22.1��0.001ƶѪ99.09.47.9